Gachev Has Gone, but Still with Us

The Kraepelinian dichotomy – going, going... but still not gone

Recent genetic studies reinforce the view that current approaches to the diagnosis and classification of major psychiatric illness are inadequate. These findings challenge the distinction between schizophrenia and bipolar disorder, and suggest that more attention should be given to the relationship between the functional psychoses and neurodevelopmental disorders such as autism. We are entering...

Digitalis reappraised: Still here today, but gone tomorrow?

Digoxin is one of the oldest of drugs acting on the heart and still one of the most frequently used. While in atrial fibrillation digoxin continues to have a valid role in the control of ventricular rate when added to beta-blockers and calcium antagonists, digoxin for heart failure is no longer a supportable option in view of the negative recent meta-analysis.

Coronavirus: Where Has All the Health Economics Gone?

As the coronavirus disease 2019 (COVID-19) pandemic continues to unfold there is an untold number of trade-offs being made in every country around the globe. The experience in the United Kingdom and Canada to date has not seen much uptake of health economics methods. We provide some thoughts on how this could take place, specifically in three areas. Firstly, this can involve understanding the i...

Has the manual gone mental?

The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), to be published in May, will include highly controversial changes. Some diagnoses have been broadened to include a range of behaviours hitherto considered normal. As the coverage of mental disorder diagnoses increases, is there any space left for normal biological variability in human behaviour? Michael Gros...

Has Goodwill Accounting Gone Bad?